Pair Name	Oridonin, Venetoclax
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Expression	BAD	hsa572
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL-xL	hsa598
	Up-regulation	Expression	BIM	hsa10018
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Phosphorylation	CDK2	hsa1017
	Up-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Phosphorylation	GSK3B	hsa2932
	Up-regulation	Expression	H2AX	hsa3014
	Down-regulation	Expression	MCL1	hsa4170
	Down-regulation	Expression	MDM2	hsa4193
	Down-regulation	Expression	MYC	hsa4609
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	MOLM-13	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_2119
	OCI-AML-3	Adult acute myeloid leukemia	Homo sapiens (Human)	CVCL_1844
	U-937	Adult acute monocytic leukemia	Homo sapiens (Human)	CVCL_0007
	THP-1	Childhood acute monocytic leukemia	Homo sapiens (Human)	CVCL_0006
In Vivo Model	5×10⁶ OCI-AML3 cells stably expressing luciferase were injected into the tail vein of NTG mice, and in vivo imaging was performed on the fourth day to confirm successful establishment of the AML xenografts.
Result	Oridonin and venetoclax synergistically promote AML cell apoptosis by inhibiting AKT signaling.